Bruton and Tec: New Links in Osteoimmunology
نویسندگان
چکیده
منابع مشابه
New Tec - : hniqtws for
We present; t,wo new t.~·r·ln!iqnr:-s for con~l.rnct.ing 1.EC/AUED codes. The cnmbiu~t.ion 'lf the l.wn L<'c!tniqnf"s rednce!l the t,otal rednnda.nry of t,h,. hr:-st r·nnsl.rll(~tions hy on" hit. or 11101'<' in 111<1.ny c<J.SPS.
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The concept of osteoimmunology is based on growing insight into the links between the immune system and bone at the anatomical, vascular, cellular, and molecular levels. In both rheumatoid arthritis (RA) and ankylosing spondylitis (AS), bone is a target of inflammation. Activated immune cells at sites of inflammation produce a wide spectrum of cytokines in favor of increased bone resorption in ...
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The concept of osteoimmunology was established more than a decade ago and is based on the reciprocal relationship between immune and bone cells. This way of looking to these two organs skeletal and immune system, has resulted in the development of clinical therapeutics for seemingly disparate but linked by the common themes of inflammation and bone remodeling. 1 Osteoimmunology includes osteopo...
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Osteoimmunology is the emerging concept that certain molecules link the skeletal and immune systems. The transcription factor c-Fos, a component of activator protein-1 (AP-1), is essential for osteoclast differentiation. Mice lacking c-Fos are osteopetrotic owing to impaired osteoclast development. Recent studies suggest that in contrast to this positive role in osteoclastogenesis, c-Fos expres...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2008
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2008.03.013